Article

Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α

2020-06-03

Abstract excerpt

<h4>ABSTRACT</h4> Metabolic dysfunction underlies several chronic diseases, many of which are exacerbated by obesity. Dietary interventions can reverse metabolic declines and slow aging, although compliance issues remain paramount. 17α-estradiol treatment improves metabolic parameters and slows aging in male mice. The mechanisms by which 17α-estradiol elicits these benefits remain unresolved. Herein, we show that...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e185f3bc-b3ba-5e0d-905c-6c6b311ae6c8
DOI: 10.1101/2020.06.02.130674

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor αDOI 10.1101/2020.06.02.130674Read

17α-Estradiol Modulates IGF1 and Hepatic Gene Expression in a Sex-Specific MannerSemantic proximity Read

Hepatocyte ERα orchestrates sex-specific liver adaptation to fasting and feeding statesSemantic proximity Read

Diet-induced obesity mediated through Estrogen-Related Receptor α is independent of intestinal functionSemantic proximity Read

Estrogens and Body Weight Regulation in Men.Semantic proximity Read

An Essential Role for Liver ERα in Coupling Hepatic Metabolism to the Reproductive CycleSemantic proximity Read

Metabolic and Epigenetic Regulation by Estrogen in AdipocytesSemantic proximity Read

17α-Estradiol Confers Limited Protection Against <i>APOE4</i> Phenotypes in Middle-Aged Female MiceSemantic proximity Read

Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosisSemantic proximity Read

The role of ovarian hormone dynamics in metabolic phenotype and gene expression in female mice.Semantic proximity Read

Hepatic adropin is regulated by estrogen and contributes to adverse metabolic phenotypes in ovariectomized mice.Semantic proximity Read

Estrogen receptor activation remodels <i>TEAD1</i> gene expression to alleviate nonalcoholic fatty liver diseaseSemantic proximity Read

The multiple universes of estrogen-related receptor α and γ in metabolic control and related diseasesSemantic proximity Read