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Article

Loss of ERα partially reverses the effects of maternal high-fat diet on energy homeostasis in female mice.

Scientific reports - 25 Jul 2017

Roepke Troy A, Yasrebi Ali, Villalobos Alejandra, Krumm Elizabeth A, Yang Jennifer A, Mamounis Kyle J

Abstract excerpt

Maternal high-fat diet (HFD) alters hypothalamic developmental programming and disrupts offspring energy homeostasis in rodents. 17β-estradiol (E2) also influences hypothalamic programming through estrogen receptor (ER) α. Therefore, we hypothesized that females lacking ERα would be more susceptible to maternal HFD. To address this question, heterozygous ERα knockout (WT/KO) dams were fed a control breeder chow...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28743985
DOI: 10.1038/s41598-017-06560-x
PMCID: PMC5526977

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