Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha.

Molecular and cellular biology - 1 Nov 2003

Luo Jiangming, Sladek Robert, Carrier Julie, Bader Jo-Ann, Richard Denis, Giguère Vincent

Abstract excerpt

The estrogen-related receptor alpha (ERRalpha) is an orphan member of the superfamily of nuclear hormone receptors expressed in tissues that preferentially metabolize fatty acids. Despite the molecular characterization of ERRalpha and identification of target genes, determination of its physiological function has been hampered by the lack of a natural ligand. To further understand the in vivo function of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue
Share to Body Weight
Share to Dietary Fats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Energy Metabolism

Share to Lipids

Share to Organ Size

Share to Receptors, Cytoplasmic and Nuclear

Share to Receptors, Estrogen

Source

Open in PubMed Open full text

Identifiers

PMID: 14585956
DOI: 10.1128/MCB.23.22.7947-7956.2003
PMCID: PMC262360

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha.PMID 14585956Read ↗

Estrogen-related Receptor α (ERRα) Is a Transcriptional Regulator of Apolipoprotein A-IV and Controls Lipid Handling in the IntestineSemantic proximity Read ↗

Loss of ERα partially reverses the effects of maternal high-fat diet on energy homeostasis in female mice.Semantic proximity Read ↗

Diet-induced obesity mediated through Estrogen-Related Receptor α is independent of intestinal functionSemantic proximity Read ↗

Reproductive phenotypes in the estrogen receptor-alpha knockout mouse.Semantic proximity Read ↗

Estrogen receptor knockout mice: phenotypes in the female reproductive tract.Semantic proximity Read ↗

Genomic Convergence among ERRα, PROX1, and BMAL1 in the Control of Metabolic Clock OutputsSemantic proximity Read ↗

The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesisSemantic proximity Read ↗

Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity.Semantic proximity Read ↗

Estrogen receptor-associated receptor α and peroxisome proliferator-activated receptor γ in metabolism and disease (Review)Semantic proximity Read ↗

ERRα as a Bridge Between Transcription and Function: Role in Liver Metabolism and DiseaseSemantic proximity Read ↗

Absence of ERRα in Female Mice Confers Resistance to Bone Loss Induced by Age or Estrogen-DeficiencySemantic proximity Read ↗

Nuclear receptors in disease: the oestrogen receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.