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Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosis

8 Mar 2024

Abstract excerpt

Sex-based differences in obesity-related hepatic malignancies suggest the protective roles of estrogen. Using a preclinical model, we dissected estrogen receptor (ER) isoform-driven molecular responses in high-fat diet (HFD)-induced liver diseases of male and female mice treated with or without an estrogen agonist by integrating liver multi-omics data. We found that selective ER activation recovers HFD-induced...

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PMID: 38459198
DOI: 10.1038/s44320-024-00024-x

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