Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic programming of estrogen receptor in adipocytes by high-fat diet regulates obesity-induced inflammation

26 Aug 2025

Abstract excerpt

Adipose inflammation plays a key role in obesity-induced metabolic abnormalities. Epigenetic regulation, including DNA methylation, is a molecular link between environmental factors and complex diseases. Here we found that high-fat diet (HFD) feeding induced a dynamic change of DNA methylome in mouse white adipose tissue (WAT) analyzed by reduced representative bisulfite sequencing. Interestingly, DNA methylation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipokines, Inflammation, and Metabolic Diseases
Share to Adipose Tissue and Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40857119
DOI: 10.1172/jci.insight.173423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic programming of estrogen receptor in adipocytes by high-fat diet regulates obesity-induced inflammationPMID 40857119Read ↗

Epigenetic Programming of Estrogen Receptor in Adipose Tissue by High Fat Diet Regulates Obesity-Induced InflammationSemantic proximity Read ↗

Epigenetic modifications in obesity‐associated diseasesSemantic proximity Read ↗

Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistanceSemantic proximity Read ↗

Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetesSemantic proximity Read ↗

High-fat diet induced obesity alters Dnmt1 and Dnmt3a levels and global DNA methylation in mouse ovary and testisSemantic proximity Read ↗

Epigenetic modifications in adipose tissue – relation to obesity and diabetesSemantic proximity Read ↗

Diet-induced obesity mediated through Estrogen-Related Receptor α is independent of intestinal functionSemantic proximity Read ↗

Epigenetic Remodeling in Obesity-Related Vascular DiseaseSemantic proximity Read ↗

Metabolic and Epigenetic Regulation by Estrogen in AdipocytesSemantic proximity Read ↗

Correlation between insulin-induced estrogen receptor methylation and atherosclerosis.Semantic proximity Read ↗

Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesisSemantic proximity Read ↗

Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.