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Estrogen-related Receptor α (ERRα) Is a Transcriptional Regulator of Apolipoprotein A-IV and Controls Lipid Handling in the Intestine

5 Oct 2004

Abstract excerpt

The estrogen-related receptor alpha (ERRalpha) is an orphan member of the superfamily of nuclear receptors involved in the control of energy metabolism. In particular, ERRalpha induces a high energy expenditure in the presence of the coactivator PGC-1alpha. However, ERRalpha knockout mice have reduced fat mass and are resistant to diet-induced obesity. ERRalpha is expressed in epithelial cells of the small...

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PMID: 15466464
DOI: 10.1074/jbc.m410337200

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Estrogen-related Receptor α (ERRα) Is a Transcriptional Regulator of Apolipoprotein A-IV and Controls Lipid Handling in the IntestinePMID 15466464Read ↗

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Genomic Convergence among ERRα, PROX1, and BMAL1 in the Control of Metabolic Clock OutputsSemantic proximity Read ↗

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The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha).Semantic proximity Read ↗

High-fat diet impacts the colon and its transcriptome in a sex-dependent manner that is modifiable by estrogensSemantic proximity Read ↗

Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscleSemantic proximity Read ↗

Hepatocyte ERα orchestrates sex-specific liver adaptation to fasting and feeding statesSemantic proximity Read ↗

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