Back to search

Article

Temporally overlapping mechanisms diversify clonal B cell responses <i>in vivo</i>

2024-12-21

Abstract excerpt

Naive B cells amplify and diversify their responses when activated by cognate antigen, via Myc-dependent clonal expansion, immunoglobulin class switch recombination (CSR), phenotypic variation, and somatic hypermutation (SHM). Whether these mechanisms act combinatorially in vivo to diversify clonal responses to a single pathogen remains unclear. Since diversity in the antigenic targets, functional classes, and pro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c8f4f257-5c8d-5df9-9576-8376e15c3fa6
DOI
10.1101/2024.12.17.628863
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Temporally overlapping mechanisms diversify clonal B cell responses <i>in vivo</i>DOI 10.1101/2024.12.17.628863
Phenotypic determinism and stochasticity in antibody repertoires of clonally expanded plasma cellsSemantic proximity
Maturation Trajectories and Transcriptional Landscape of Plasmablasts and Autoreactive B Cells in COVID-19Semantic proximity
Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19Semantic proximity
SeQuoIA: a single-cell BCR sequencing analysis pipeline for tracking selection mechanisms in germinal centresSemantic proximity
Memory B cells dominate the early antibody-secreting cell response to SARS-CoV-2 mRNA vaccination in naïve individuals independently of their antibody affinitySemantic proximity
Phenotypic determinism and stochasticity in antibody repertoires of clonally expanded plasma cellsSemantic proximity
Restricted Clonality and Limited Germinal Center Reentry Characterize Memory B Cell Reactivation by BoostingSemantic proximity
Complexity of the human memory B-cell compartment is determined by the versatility of clonal diversification in germinal centers.Semantic proximity
Two distinct durable human class-switched memory B cell populations are induced by vaccination and infectionSemantic proximity
Plasmodium infection induces phenotypic, clonal, and spatial diversity among differentiating CD4+ T cells.Semantic proximity
A Germinal Center–Independent Innate-Like Memory B Cell Compartment of B1 OriginSemantic proximity
Clonally distinct differentiation trajectories shape CD8 <sup>+</sup> memory T cell heterogeneity after acute viral infections in humansSemantic proximity
Select a neighboring publication to make it the new centre.