Article
Deletion of Histone Methyltransferase G9a Suppresses Mutant Kras-driven Pancreatic Carcinogenesis.
Cancer genomics & proteomics - 1 Jan 2000
Kato Hiroyuki, Tateishi Keisuke, Fujiwara Hiroaki, Ijichi Hideaki, Yamamoto Keisuke, Nakatsuka Takuma, Kakiuchi Miwako, Sano Makoto, Kudo Yotaro, Hayakawa Yoku, Nakagawa Hayato, Tanaka Yasuo, Otsuka Motoyuki, Hirata Yoshihiro, Tachibana Makoto, Shinkai Yoichi, Koike Kazuhiko
Abstract excerpt
BACKGROUND/AIM: The entire mechanisms by which epigenetic modifiers contribute to the development of pancreatic cancer remain unknown. Although the histone methyltransferase G9a is a promising target in human cancers, its role in pancreatic carcinogenesis has been under-studied. The aim of the study was to examine the role of G9a in pancreatic carcinogenesis by a gene-targeting mouse model. MATERIALS AND METHODS:...
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