Article

BIN1 deficiency leads to DNA damage and neuronal insulin resistance through ATM dysregulation

2025-08-21

Abstract excerpt

The major neuronal isoform of the AD risk gene BIN1 is specifically reduced in patients. In the present work, we demonstrate that BIN1 is necessary for intact insulin signaling and its loss leads to cellular-level insulin resistance. Persistently activated mTORC1 feedback inhibits the insulin signaling; meanwhile, ATM-dependent DNA Damage Response decreases the expression of multiple insulin signaling pathway memb...

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Literature Corpus work: c8db6dbf-c63f-5ad9-a10b-74831fded09a
DOI: 10.1101/2025.08.20.671271

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