Article

BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr <sup>348</sup> phosphorylation

2018-11-07

Abstract excerpt

The bridging integrator 1 gene ( BIN1 ) is a major genetic risk factor for Alzheimer’s disease (AD). In this report, we investigated how BIN1-dependent pathophysiological processes might be associated with Tau. We first generated a cohort of control and transgenic mice either overexpressing human MAPT (Tg MAPT ) or both human MAPT and BIN1 (Tg MAPT ;Tg BIN1 ), which we followed-up from 3 to 15 months. In Tg M...

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Literature Corpus work: 909bb553-17d7-57b6-993e-c56b93c42375
DOI: 10.1101/462317

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