Article

Predicting developmental relationships of tumor resident and circulating T cells in ovarian cancer

2023-03-01

Abstract excerpt

<h4>ABSTRACT</h4> Characterizing T cell populations and understanding their developmental relationships may help design more effective cancer immunotherapies. We coupled single-cell transcriptomics and T cell receptor (TCR) αβ profiling of intratumoral and peripheral T cells in ovarian cancer patients to identify transcriptional programs and infer their relationship by trajectory and TCR overlap analyses. We prop...

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Literature Corpus work: c8ced60e-c723-583e-ae5b-0cb160d6b465
DOI: 10.1101/2023.02.28.530488

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