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Characterizing the tumor microenvironment of metastatic ovarian cancer by single-cell transcriptomics

1 May 2021

Abstract excerpt

Understanding the cellular composition of the tumor microenvironment and the interactions of the cells is essential to the development of successful immunotherapies in cancer. We perform single-cell RNA sequencing (scRNA-seq) of 9,885 cells isolated from the omentum in 6 patients with ovarian cancer and identify 9 major cell types, including cancer, stromal, and immune cells. Transcriptional analysis of immune...

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PMID: 34038734
DOI: 10.1016/j.celrep.2021.109165

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