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Exhausted CD8⁺ T Cells Promote Ovarian Cancer Immunosuppression via CCL3-Driven M2 Macrophage Polarization

2025-12-08

Abstract excerpt

<title>Abstract</title> <p>High-grade serous ovarian cancer (HGSOC) is an aggressive malignancy marked by high recurrence rates, poor prognosis, and limited response to immune checkpoint inhibitors, primarily attributable to its immunologically “cold” tumor microenvironment. To profile the immunological landscape of HGSOC, we conducted single-cell RNA sequencing (scRNA-seq) on 84,065 cells from tumor tissues of e...

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Literature Corpus work: f1ddfbbc-bb4a-5872-85e3-90e48234708e
DOI: 10.21203/rs.3.rs-8074255/v1

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