Article

Aberrant pace of cortical neuron development in brain organoids from patients with 22q11.2 deletion syndrome-associated schizophrenia

2023-10-05

Abstract excerpt

Adults and children afflicted with the 22q11.2 deletion syndrome (22q11.2DS) exhibit cognitive, social, and emotional impairments, and are at significantly heightened risk for schizophrenia (SCZ). The impact of this deletion on early human brain development, however, has remained unclear. Here we harness organoid models of the developing human cerebral cortex, cultivated from subjects with 22q11.2DS and SCZ, as we...

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Literature Corpus work: c8be7ab7-fe33-5a01-8aa9-cb621e07ef33
DOI: 10.1101/2023.10.04.557612

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