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Article

Altered function and maturation of primary cortical neurons from a 22q11.2 deletion mouse model of schizophrenia

17 Apr 2018

Abstract excerpt

Abstract Given its high penetrance, clearly delineated and evolutionary conserved genomic structure, mouse models of the 22q11.2 deletion provide an ideal organism-based and cell-based model of this well-established disease mutation for schizophrenia. In this study we examined the development of changes in intrinsic properties, action potential firing and synaptic transmission using whole-cell patch-clamp...

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PMID: 29666363
DOI: 10.1038/s41398-018-0132-8

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