Article

Cortical Organoids Model Early Brain Development Disrupted by 16p11.2 Copy Number Variants in Autism

2020-06-27

Abstract excerpt

Reciprocal deletion and duplication of 16p11.2 region is the most common copy number variation (CNV) associated with Autism Spectrum Disorders. We generated cortical organoids from skin fibroblasts of patients with 16p11.2 CNV to investigate impacted neurodevelopmental processes. We show that organoid size recapitulates macrocephaly and microcephaly phenotypes observed in the patients with 16p11.2 deletions and du...

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Literature Corpus work: f139c55d-aab2-5d42-9379-1db730e6af32
DOI: 10.1101/2020.06.25.172262

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