Article

Asynchronous excitatory neuron development in an isogenic cortical spheroid model of Down syndrome

2022-05-01

Abstract excerpt

The intellectual disability (ID) in Down syndrome (DS) is thought to result from a variety of developmental deficits such as alterations in neural progenitor division, neurogenesis, gliogenesis, cortical architecture, and reduced cortical volume. However, the molecular processes underlying these neurodevelopmental changes are still elusive, preventing an understanding of the mechanistic basis of ID in DS. In this...

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Literature Corpus work: 6679e2a8-e72c-52be-a956-971f9169080e
DOI: 10.1101/2022.04.30.490174

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