Article

Cerebral organoid proteomics reveals signatures of dysregulated cortical development associated with human trisomy 21

2018-05-05

Abstract excerpt

<h4>SUMMARY</h4> Human trisomy 21 (Down syndrome) is the most common genetic cause of intellectual disability, and is associated with complex perturbations in protein expression during development. Brain region-specific alterations in neuronal density and composition originate prenatally in trisomy 21 individuals, and are presumed to underlie the intellectual disability and early onset neurodegeneration that char...

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Literature Corpus work: 334f1a30-94bf-5f79-980b-e20cc1dc5358
DOI: 10.1101/315317

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