Article

22q11 deletion selectively alters progenitor states and projection neuron identities in the developing cerebral cortex

2025-05-29

Abstract excerpt

<title>Abstract</title> <p>Heterozygous deletion of multiple contiguous genes associated with 22q11.2 Deletion Syndrome (22q11DS), a developmental disorder with significant risk for autistic spectrum disorder (ASD) and schizophrenia (Scz), selectively compromises neurogenic capacities of a temporally distinct cohort of cerebral cortical basal progenitors (bPs), prefiguring diminished frequency, divergent times of...

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Literature Corpus work: 26e556db-2f51-56f3-950c-40f6cf73d304
DOI: 10.21203/rs.3.rs-6531749/v1

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