Article

Oligodendrocyte Enriched Brain Organoids Reveal Impaired Oligodendroglial Maturation and Altered Neural Network Activity in Down Syndrome

2026-08-28

Abstract excerpt

Individuals with Down syndrome (DS) display developmental delay, intellectual disability, premature brain ageing, and an increased risk of Alzheimer-like neurodegeneration. Although the neuropathology of the postnatal and adult DS brain has been widely described, it remains unclear how trisomy 21 alters early human neural and glial development. Here, we used human oligodendrocyte enriched brain organoids derived f...

Topics

Open a Topic to create a Post that cites this publication.

Uncategorized literature

Identifiers and source

Literature Corpus work: 0fe1d200-f889-5a2c-bcae-2285c372e5c8
DOI: 10.64898/2026.08.27.747500

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Oligodendrocyte Enriched Brain Organoids Reveal Impaired Oligodendroglial Maturation and Altered Neural Network Activity in Down SyndromeDOI 10.64898/2026.08.27.747500Read

Asynchronous excitatory neuron development in an isogenic cortical spheroid model of Down syndromeSemantic proximity Read

Astrocytes in Down Syndrome Across the LifespanSemantic proximity Read

Abnormal neuronal and synaptic morphology in Down syndrome brains reproduces in human isogenic cellular modelsSemantic proximity Read

Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and MyelinationSemantic proximity Read

Transcriptional consequences of trisomy 21 on neural inductionSemantic proximity Read

Integration-free induced pluripotent stem cells model genetic and neural developmental features of down syndrome etiology.Semantic proximity Read

Trisomy 21 Impairs Synchronized Activity in Human Down Syndrome Cortical Excitatory Neuron NetworksSemantic proximity Read

Aberrant pace of cortical neuron development in brain organoids from patients with 22q11.2 deletion syndrome-associated schizophreniaSemantic proximity Read

Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21Semantic proximity Read

Accelerated Tempo of Cortical Neurogenesis in Down SyndromeSemantic proximity Read

Single cell atlas of trisomy 21 cerebral cortexSemantic proximity Read