Article

Transient disruption of progenitor states and layer 2/3 projection neuron generation in frontal association cortex due to 22q11.2 gene deletion

2025-05-13

Abstract excerpt

<h4>ABSTRACT</h4> The developmental origin of Layer 2/3 projection neuron (PN) pathology in the frontal association cortex due to heterozygous 22q11 gene deletion—the genetic foundation of elevated risk for schizophrenia and related psychiatric disorders in 22q11.2 Deletion Syndrome (22q11DS)—reflects cell state-dependent, temporally restricted vulnerability of transcriptionally diverse subsets of intermediate pr...

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Literature Corpus work: ca58b624-3451-5ade-af36-d5c86155e0ef
DOI: 10.1101/2025.05.12.653556

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