Article

Metastasis-associated wound repair promotes reciprocal activation of the lung epithelium and breast cancer metastases during outgrowth

2025-07-27

Abstract excerpt

<h4>ABSTRACT</h4> When tumor cells colonize distant organs during metastasis, they interact extensively with surrounding cells. These interactions often change the behavior of surrounding cell populations which collectively induce a pro-tumor microenvironment that permits tumor cell outgrowth into overt, clinically detectable metastatic disease. The lung is one of the most common sites of breast cancer (BC) metas...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c8b340d7-af09-5d01-aad5-48436e0f24b7
DOI: 10.1101/2025.07.23.666437

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Metastasis-associated wound repair promotes reciprocal activation of the lung epithelium and breast cancer metastases during outgrowthDOI 10.1101/2025.07.23.666437Read

A human lung organoid co-culture model of early bone sarcoma metastasis reveals contact-dependent epithelial remodeling at the metastatic interfaceSemantic proximity Read

Altered Expression of Secreted Mediator Genes That Mediate Aggressive Breast Cancer Metastasis to Distant OrgansSemantic proximity Read

Evolution of metastases-associated fibroblasts in the lung microenvironment is driven by stage-specific transcriptional plasticitySemantic proximity Read

Spontaneous regression of micro-metastases following primary tumor excision: a critical role for primary tumor secretomeSemantic proximity Read

Maintenance of epithelial traits and resistance to mesenchymal reprogramming promote proliferation in metastatic breast cancerSemantic proximity Read

Cancer cell – fibroblast crosstalk via HB-EGF/EGFR/MEK signaling promotes macrophage recruitment in squamous cell carcinomaSemantic proximity Read

Differential Adaptation and Remodeling of the Tumor Microenvironment in Breast Cancer Cells During the Stages of Brain MetastasisSemantic proximity Read

Multidimensional analysis to elucidate the possible mechanism of bone metastasis in breast cancerSemantic proximity Read

Hypoxic niche drives lineage imbalance and early tumorigenesis in EGFR-mutant lung cancer.Semantic proximity Read

Mesenchymal stem cells mediate the clinical phenotype of inflammatory breast cancer in a preclinical model.Semantic proximity Read

Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer.Semantic proximity Read

Aberrant activation of wound healing programs within the metastatic niche facilitates lung colonization by osteosarcoma cellsSemantic proximity Read