Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer.

doi:10.1242/dmm.017830

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Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer.

Disease models & mechanisms - 1 Mar 2015

Johnstone Cameron N, Smith Yvonne E, Cao Yuan, Burrows Allan D, Cross Ryan S N, Ling Xiawei, Redvers Richard P, Doherty Judy P, Eckhardt Bedrich L, Natoli Anthony L, Restall Christina M, Lucas Erin, Pearson Helen B, Deb Siddhartha, Britt Kara L, Rizzitelli Alexandra, Li Jason, Harmey Judith H, Pouliot Normand, Anderson Robin L

Abstract excerpt

The translation of basic research into improved therapies for breast cancer patients requires relevant preclinical models that incorporate spontaneous metastasis. We have completed a functional and molecular characterisation of a new isogenic C57BL/6 mouse model of breast cancer metastasis, comparing and contrasting it with the established BALB/c 4T1 model. Metastatic EO771.LMB tumours were derived from poorly...

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PMID: 25633981
DOI: 10.1242/dmm.017830
PMCID: PMC4348562

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EGFR

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