Article
Mesenchymal stem cells mediate the clinical phenotype of inflammatory breast cancer in a preclinical model.
Breast cancer research : BCR - 20 Mar 2015
Lacerda Lara, Debeb Bisrat G, Smith Daniel, Larson Richard, Solley Travis, Xu Wei, Krishnamurthy Savitri, Gong Yun, Levy Lawrence B, Buchholz Thomas, Ueno Naoto T, Klopp Ann, Woodward Wendy A
Abstract excerpt
INTRODUCTION: Inflammatory breast cancer (IBC) is an aggressive type of breast cancer, characterized by very rapid progression, enlargement of the breast, skin edema causing an orange peel appearance (peau d'orange), erythema, thickening, and dermal lymphatic invasion. It is characterized by E-cadherin overexpression in the primary and metastatic disease, but to date no robust molecular features that specifically...
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