Article

Cancer cell – fibroblast crosstalk via HB-EGF/EGFR/MEK signaling promotes macrophage recruitment in squamous cell carcinoma

2023-07-14

Abstract excerpt

<h4>Summary</h4> Interactions between cells in the tumor microenvironment (TME) shape cancer progression and patient outcomes. To gain new insights into how the TME influences cancer outcomes, we derive gene expression signatures indicative of signaling between stromal fibroblasts and cancer cells, and demonstrate their prognostic significance in multiple and independent squamous cell carcinoma cohorts. By levera...

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Literature Corpus work: bdea94da-605c-53fa-8682-d9f25e458af0
DOI: 10.1101/2023.07.13.548733

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