Article

Differential Adaptation and Remodeling of the Tumor Microenvironment in Breast Cancer Cells During the Stages of Brain Metastasis

2023-07-15

Abstract excerpt

<h4>Objective</h4> To integrate macro-transcriptomics and single-cell sequencing to analyze the differential gene expression between primary and brain metastatic breast cancer cells, as well as between active and dormant cancer cells within brain metastases, exploring their adaptation and remodeling abilities at different stages of brain metastasis. <h4>Methods</h4> Four public datasets were used: three mRNA mic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fb70c63e-e9ec-5519-b8bb-5f8cf189210b
DOI: 10.1101/2023.07.13.548875

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Differential Adaptation and Remodeling of the Tumor Microenvironment in Breast Cancer Cells During the Stages of Brain MetastasisDOI 10.1101/2023.07.13.548875Read

Single-cell RNA sequencing reveals route-specific remodeling of the tumor microenvironment and identifies predictive factors of breast cancer metastasisSemantic proximity Read

Single-cell transcriptomics provide insight into metastasis-related subsets of breast cancerSemantic proximity Read

Gene expression predicts dormant metastatic breast cancer cell phenotype.Semantic proximity Read

Dissecting the contributions of tumor heterogeneity on metastasis at single-cell resolutionSemantic proximity Read

Single-cell profiling transcriptomic reveals cellular heterogeneity and cellular crosstalk in breast cancer lymphatic node, bone, and brain metastasesSemantic proximity Read

Beyond Genetics: Metastasis as an Adaptive Response in Breast CancerSemantic proximity Read

Decoding the adaptive survival mechanisms of breast cancer dormancySemantic proximity Read

Single-cell analysis reveals inter- and intratumour heterogeneity in metastatic breast cancerSemantic proximity Read

Single-cell Analysis Reveals Inter- and Intratumour Heterogeneity in Metastatic Breast CancerSemantic proximity Read

Single‐cell RNA sequencing elucidated the landscape of breast cancer brain metastases and identified ILF2 as a potential therapeutic targetSemantic proximity Read

Single-cell sequencing reveals the landscape of the human brain metastatic microenvironmentSemantic proximity Read

Developing a dormancy-associated ECM signature in TNBC that is linked to immunosuppressive tumor microenvironment and selective sensitivity to MAPK inhibitorsSemantic proximity Read