Article

A human lung organoid co-culture model of early bone sarcoma metastasis reveals contact-dependent epithelial remodeling at the metastatic interface

2026-06-08

Abstract excerpt

Lung metastasis drives mortality across cancer types, yet how infiltrating tumor cells remodel the lung epithelium to establish metastatic niches remains poorly understood. Here we establish MESCUL (MEtastatic Sarcoma Co-CULture), a co-culture platform combining human lung organoids with patient-derived bone sarcoma cells to model early tumor–lung epithelial interactions in a physiologically relevant 3D system. ME...

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Literature Corpus work: bf32e5d5-0346-5daf-ab4e-1ced828f9734
DOI: 10.64898/2026.06.03.729838

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