Article

Decreased expression of ribosomal protein Rpl3 contributes to behavioral deficits caused by Shank3 deficiency

2023-04-25

Abstract excerpt

<title>Abstract</title> <p>Mutations or deletions in the SHANK3 gene have been identified in up to 1% of autism spectrum disorder cases and are considered the main cause of neuropsychiatric symptoms of Phelan McDermid syndrome (PMS). While in the absence of Shank3, synaptic dysfunctions have been extensively described, other mechanisms through which Shank3 could regulate neuronal functions have not been clearly e...

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Literature Corpus work: c81de682-160e-57cf-8758-3e329338c0bb
DOI: 10.21203/rs.3.rs-2812308/v1

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