Article

Reduced Brain Volume and White Matter Alterations in Shank3-Deficient Rats

2020-11-04

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: Mutations and deletions in the <italic>SHANK3</italic> synaptic gene cause the major neurodevelopmental features of Phelan-McDermid syndrome (PMS). The <italic>SHANK3</italic> gene encodes a key structural component of excitatory synapses that is important for synaptogenesis. PMS is characterized by intellectual disability, autism spectrum disorder, cognitive de...

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Literature Corpus work: 31bdd78a-8643-5464-b379-8c9a510c8f2e
DOI: 10.21203/rs.3.rs-100329/v1

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