Article

Shank3 insufficiency is associated with age-dependent mitochondrial dysfunction in dendritic and synaptic compartments

2026-08-26

Abstract excerpt

<title>Abstract</title> <p> SHANK3 is an important scaffolding protein at the post-synapse of excitatory neurons and its haploinsufficiency is associated with a syndromic form of autism spectrum disorder (ASD) called the Phelan-McDermid Syndrome (PMS). Previous results have linked insufficient Shank3 levels at the synapse to impaired protein translation that could be due - at least in part- to limited energy sup...

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Literature Corpus work: b6f3047e-d3a8-52c7-82c6-f6fef4cccf1d
DOI: 10.21203/rs.3.rs-10661517/v1

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