Article
Folding of polyglutamine chains.
The Journal of chemical physics - 7 Oct 2008
Chopra Manan, Reddy Allam S, Abbott N L, de Pablo J J
Abstract excerpt
Long polyglutamine chains have been associated with a number of neurodegenerative diseases. These include Huntington's disease, where expanded polyglutamine (PolyQ) sequences longer than 36 residues are correlated with the onset of symptoms. In this paper we study the folding pathway of a 54-residue PolyQ chain into a beta-helical structure. Transition path sampling Monte Carlo simulations are used to generate...
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