Article

Integrative Genomic and Immune Repertoire Profiling Identifies Clonal Signatures Linked to Antithyroid Drug-Induced Agranulocytosis

2025-12-01

Abstract excerpt

<h4>ABSTRACT</h4> Graves’ disease (GD) is the leading cause of hyperthyroidism and is often treated with antithyroid drugs (ATDs). Although ATD therapy is effective, it might cause a rare but serious adverse effect called ATD-induced agranulocytosis (TiA), which can lead to severe neutropenia and life-threatening infections. Previous studies have shown that certain human leukocyte antigen (HLA) alleles, including...

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Literature Corpus work: c80f4ab7-2e84-575d-ac22-82f1e6038303
DOI: 10.1101/2025.11.27.25341185

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