Article

Pathogenesis of Graves' Disease Determined Using Single-Cell Sequencing with Thyroid Autoantigens Peptides Stimulation in B Cells

2025-04-03

Abstract excerpt

<title>Abstract</title> <p>This study reports the use of single-cell RNA sequencing to evaluate B cells in the peripheral blood mononuclear cells (PBMCs) and intrathyroidal blood mononuclear cells of patients with Graves’ disease (GD) undergoing thyroidectomy. These cells were stimulated with overlapping peptides of thyroid autoantigens, including thyroid-stimulating hormone receptor (Lgr3), thyroglobulin (Tg), a...

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Literature Corpus work: 55450177-e084-5703-82d8-a7bf1178607b
DOI: 10.21203/rs.3.rs-6167157/v1

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