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Article

Informatics investigations into anti-thyroid drug induced agranulocytosis associated with multiple HLA-B alleles.

PloS one - 1 Jan 2020

Ramsbottom Kerry A, Carr Daniel F, Rigden Daniel J, Jones Andrew R

Abstract excerpt

INTRODUCTION: Adverse drug reactions have been linked with HLA alleles in different studies. These HLA proteins play an essential role in the adaptive immune response for the presentation of self and non-self peptides. Anti-thyroid drugs methimazole and propylthiouracil have been associated with drug induced agranulocytosis (severe lower white blood cell count) in patients with B*27:05, B*38:02 and DRB1*08:03...

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Identifiers

PMID: 32027661
DOI: 10.1371/journal.pone.0220754
PMCID: PMC7004376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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