Article
SARS-COV-2 specific t-cells in patients with thyroid disorders related to COVID-19 are enriched in the thyroid and acquire a tissue-resident memory phenotype.
Clinical immunology (Orlando, Fla.) - 1 Sept 2023
Silvestri Ylenia, Clemente Francesca, Moschetti Giorgia, Maioli Sara, Carelli Elena, Espadas de Arias Alejandro, Torelli Rosanna, Longhi Elena, De Feo Tullia, Crosti MariaCristina, Sarnicola Maria Lucia, Salvi Mario, Mantovani Giovanna, Arosio Maura, Bombaci Mauro, Pesce Elisa, Grifantini Renata, Abrignani Sergio, Geginat Jens, Muller Ilaria
Abstract excerpt
BACKGROUND: SARS-CoV-2 infections have been associated with the onset of thyroid disorders like classic subacute thyroiditis (SAT) or atypical SAT upon severe COVID disease (COV-A-SAT). Little is known about thyroid anti-viral immune responses. OBJECTIVES: To define the role of T-cells in COV-A-SAT. METHODS: T-cells from COV-A-SAT patients were analyzed by multi-dimensional flow cytometry, UMAP and DiffusionMap...
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