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Article

Pharmacogenomic screening strategy and indicative screening efficiency for antithyroid drug-induced agranulocytosis in the Southern Han Chinese.

European journal of clinical pharmacology - 11 Jul 2026

Ma Li, Ke Sujie, Huang Peiji, Chen Yao, Lin Qian, Lin Menghua, He Guanlian, Zou Laiyu, Chen Xiaoling, Liu Xiaoying, Liu Libin, Wang Lijing

Abstract excerpt

PURPOSE: Antithyroid drug-induced agranulocytosis (ATDIA) is a life-threatening adverse drug reaction with strong population-specific genetic predispositions. This study aimed to develop a pharmacogenomic risk-stratification model and to evaluate the indicative screening efficiency of targeted pretherapeutic screening in the mainland Southern Han Chinese population. METHODS: This retrospective case-control study...

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Case-Control Studies
China
East Asian People
Graves Disease
HLA-B Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-DRB1 Chains

Pharmacogenomic Testing

Polymorphism, Single Nucleotide

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PMID: 42432373
DOI: 10.1007/s00228-026-04138-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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