Article

Informatics investigations into anti-thyroid drug induced agranulocytosis associated with multiple HLA-B alleles

2019-07-25

Abstract excerpt

Adverse drug reactions have been linked with HLA alleles in different studies. These HLA proteins play an essential role in the adaptive immune response for the presentation of self and non-self peptides. Anti-thyroid drugs methimazole and propylthiouracil have been associated with drug induced agranulocytosis (severe lower white blood cell count) in patients with B*27:05, B*38:02 and DRB1*08:03 alleles in differe...

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Literature Corpus work: 302114ab-c4ff-5f26-a992-46c147c64cc1
DOI: 10.1101/713743

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