Genetic determinants of antithyroid drug-induced agranulocytosis by human leukocyte antigen genotyping and genome-wide association study.

doi:10.1038/ncomms8633

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Article

Genetic determinants of antithyroid drug-induced agranulocytosis by human leukocyte antigen genotyping and genome-wide association study.

Nature communications - 7 Jul 2015

Chen Pei-Lung, Shih Shyang-Rong, Wang Pei-Wen, Lin Ying-Chao, Chu Chen-Chung, Lin Jung-Hsin, Chen Szu-Chi, Chang Ching-Chung, Huang Tien-Shang, Tsai Keh Sung, Tseng Fen-Yu, Wang Chih-Yuan, Lu Jin-Ying, Chiu Wei-Yih, Chang Chien-Ching, Chen Yu-Hsuan, Chen Yuan-Tsong, Fann Cathy Shen-Jang, Yang Wei-Shiung, Chang Tien-Chun

Abstract excerpt

Graves' disease is the leading cause of hyperthyroidism affecting 1.0-1.6% of the population. Antithyroid drugs are the treatment cornerstone, but may cause life-threatening agranulocytosis. Here we conduct a two-stage association study on two separate subject sets (in total 42 agranulocytosis cases and 1,208 Graves' disease controls), using direct human leukocyte antigen genotyping and SNP-based genome-wide...

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PMID: 26151496
DOI: 10.1038/ncomms8633
PMCID: PMC4506516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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