Article

Robust T cell activation requires an eIF3-driven burst in T cell receptor translation

2021-10-04

Abstract excerpt

<h4>ABSTRACT</h4> Activation of T cells requires a rapid surge in cellular protein synthesis. However, the role of translation initiation in the early induction of specific genes remains unclear. Here we show human translation initiation factor eIF3 interacts with select immune system related mRNAs including those encoding the T cell receptor (TCR) subunits TCRA and TCRB. Binding of eIF3 to the TCRA and TCRB mR...

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Literature Corpus work: c7d7b667-0078-5355-be3a-a4f2505eabaf
DOI: 10.1101/2021.10.04.463005

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