Article

The earliest changes in the translatome upon human T cell activation

2025-08-01

Abstract excerpt

Stimulation of resting T cells triggers a rapid transition into an activated state, characterized by significant changes in phenotype, metabolism and secretory function. To explore the earliest responses, we examined transcriptional and translational changes in isolated human T cells within the first four hours post-stimulation. Polyclonal stimulation initially upregulates cytokine genes while downregulating certa...

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Literature Corpus work: b29447eb-5a77-510a-9fa7-ea325bda69a1
DOI: 10.1101/2025.07.31.667903

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