Article

The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAs

2018-06-22

Abstract excerpt

<h4>ABSTRACT</h4> Improper regulation of translation initiation, a vital checkpoint of protein synthesis in the cell, has been linked to a number of cancers. Overexpression of protein subunits of eukaryotic translation initiation factor 3 (eIF3) is associated with increased translation of mRNAs involved in cell proliferation. In addition to playing a major role in general translation initiation by serving as a sc...

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Literature Corpus work: c7d16a8b-3e68-5c92-95d9-32caa7e7c999
DOI: 10.1101/354399

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