Article

A burst in T cell receptor translation mediated by eIF3 interactions with T cell receptor mRNAs

2019-12-21

Abstract excerpt

Activation of T cells requires a global surge in cellular protein synthesis, accompanied by a large increase in translation initiation 1–4 . A central component of the translation initiation machinery–the multi-subunit eukaryotic initiation factor 3 (eIF3)–is rapidly turned on when quiescent T cells are stimulated 3 . However, the precise role eIF3 plays in activated T cells is not known. Using a global transcri...

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Literature Corpus work: 510b8b55-7402-5866-aa2f-4c68c1276df9
DOI: 10.1101/2019.12.20.885558

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