Article
Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation.
Nucleic acids research - 1 Aug 2013
Sun Chaomin, Querol-Audí Jordi, Mortimer Stefanie A, Arias-Palomo Ernesto, Doudna Jennifer A, Nogales Eva, Cate Jamie H D
Abstract excerpt
The initiation of protein synthesis plays an essential regulatory role in human biology. At the center of the initiation pathway, the 13-subunit eukaryotic translation initiation factor 3 (eIF3) controls access of other initiation factors and mRNA to the ribosome by unknown mechanisms. Using electron microscopy (EM), bioinformatics and biochemical experiments, we identify two highly conserved RNA-binding motifs...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.