Article

Stimulation of dysregulated IFN-β responses by aberrant SARS-CoV-2 small viral RNAs

2022-03-16

Abstract excerpt

<title>Abstract</title> <p>Patients with severe COVID-19 exhibit a cytokine storm characterized by greatly elevated levels of cytokines during worsening disease. Despite this, the interferon (IFN) response is delayed, contributing to disease progression. Here, we report that SARS-CoV-2 generates excessive amounts of small viral RNAs (svRNAs) encoding exact 5′ ends of positive-sense genes in human cells, whereas s...

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Identifiers and source

Literature Corpus work: c7cd216d-4b1d-559a-86d7-99cf55b48971
DOI: 10.21203/rs.3.rs-1271053/v2

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