Article
Defective Interfering Genomes and the Full-Length Viral Genome Trigger RIG-I After Infection With Vesicular Stomatitis Virus in a Replication Dependent Manner.
Frontiers in immunology - 1 Jan 2021
Linder Andreas, Bothe Viktoria, Linder Nicolas, Schwarzlmueller Paul, Dahlström Frank, Bartenhagen Christoph, Dugas Martin, Pandey Dharmendra, Thorn-Seshold Julia, Boehmer Daniel F R, Koenig Lars M, Kobold Sebastian, Schnurr Max, Raedler Johannes, Spielmann Giulia, Karimzadeh Hadi, Schmidt Andreas, Endres Stefan, Rothenfusser Simon
Abstract excerpt
Replication competent vesicular stomatitis virus (VSV) is the basis of a vaccine against Ebola and VSV strains are developed as oncolytic viruses. Both functions depend on the ability of VSV to induce adequate amounts of interferon-α/β. It is therefore important to understand how VSV triggers interferon responses. VSV activates innate immunity via retinoic acid-inducible gene I (RIG-I), a sensor for viral RNA....
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