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Interfering with Interferons: A Critical Mechanism for Critical COVID-19 Pneumonia

26 Apr 2023

Abstract excerpt

Infection with SARS-CoV-2 results in clinical outcomes ranging from silent or benign infection in most individuals to critical pneumonia and death in a few. Genetic studies in patients have established that critical cases can result from inborn errors of TLR3- or TLR7-dependent type I interferon immunity, or from preexisting autoantibodies neutralizing primarily IFN-α and/or IFN-ω. These findings are consistent...

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PMID: 37126418
DOI: 10.1146/annurev-immunol-101921-050835

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