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A virus‐derived microRNA targets immune response genes during SARS‐CoV‐2 infection

16 Dec 2021

Abstract excerpt

SARS-CoV-2 infection results in impaired interferon response in patients with severe COVID-19. However, how SARS-CoV-2 interferes with host immune responses is incompletely understood. Here, we sequence small RNAs from SARS-CoV-2-infected human cells and identify a microRNA (miRNA) derived from a recently evolved region of the viral genome. We show that the virus-derived miRNA produces two miRNA isoforms in...

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PMID: 34914162
DOI: 10.15252/embr.202154341

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