Lack of detectable neoantigen depletion in the untreated cancer genome

Abstract excerpt

<h4>ABSTRACT</h4> Somatic mutations in cancer can result in the presentation of mutated peptides on the cell surface, eliciting an immune response. Mutant peptides are presented via HLA molecules and are known as neoantigens. It has been suggested that selection acts against the underlying mutations, leading to neoantigen depletion. Knowing the extent of this specific form of immunoediting may provide fundamental...

Topics

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• Antigens, Neoplasm
• Codon
• Databases, Factual
• Genome, Human
• HLA Antigens
• Mutation Rate
• Selection, Genetic
• T-Lymphocytes, Cytotoxic

Identifiers and source

Literature Corpus work

c5f89240-03a4-53a1-88fa-f67b6e92b235

DOI

10.1101/478263