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Article

A Diffusion-like Process Accommodates New Crypts During Clonal Expansion in Human Colonic Epithelium.

Gastroenterology - 1 Aug 2021

Olpe Cora, Khamis Doran, Chukanova Maria, Skoufou-Papoutsaki Nefeli, Kemp Richard, Marks Kate, Tatton Cerys, Lindskog Cecilia, Nicholson Anna, Brunton-Sim Roxanne, Malhotra Shalini, Ten Hoopen Rogier, Stanley Rachael, Winton Douglas J, Morrissey Edward

Abstract excerpt

BACKGROUND & AIMS: Colorectal cancer (CRC) is thought to arise when the cumulative mutational burden within colonic crypts exceeds a certain threshold that leads to clonal expansion and ultimately neoplastic transformation. Therefore, quantification of the fixation and subsequent expansion of somatic mutations in normal epithelium is key to understanding colorectal cancer initiation. The aim of the present study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33895166
DOI: 10.1053/j.gastro.2021.04.035
PMCID: PMC8377717

Genes

KDM6A
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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