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Article

Field cancerisation in colorectal cancer: A new frontier or pastures past?

1 Jan 2015

Abstract excerpt

Despite considerable advances in our understanding of cancer biology, early diagnosis of colorectal cancer remains elusive. Based on the adenoma-carcinoma sequence, cancer develops through the progressive accumulation of mutations in key genes that regulate cell growth. However, recent mathematical modelling suggests that some of these genetic events occur prior to the development of any discernible histological...

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PMID: 25852261
DOI: 10.3748/wjg.v21.i13.3763

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